Authors: Benjamin Gesundheit, Leah Hochbaum, Alexandra Fetyukhina, Vasily Vorobyev, Nikolay Vorobye 

Description: Autism spectrum disorder (ASD) is associated with significant lifelong challenges for severely affected children and their families. The condition remains poorly understood, and no reliable, effective treatments are available. Presented is a case of a boy with severe ASD, epilepsy, and a pathological electroencephalogram (EEG) who underwent five treatments between the ages of 5.75 years and nine years with mesenchymal stem cells from allogeneic placenta and umbilical cord tissue of unrelated donors. Read more

Publucation: Cureus, May 2025

Authors: Benjamin Gesundheit, Philip David Zisman, Leah Hochbaum, Yehudit Posen, Avraham Steinberg, Gerald Friedman, Hersh D. Ravkin, Eitan Rubin, Ouriel Faktor and Ronald Ellis

Description: Children with autism spectrum disorder (ASD) present with distinctive clinical features. No objective laboratory assay has been developed to establish a diagnosis of ASD. Considering the known immunological associations with ASD, immunological biomarkers might enable ASD diagnosis and intervention at an early age when the immature brain has the highest degree of plasticity. This work aimed to identify diagnostic biomarkers discriminating between children with ASD and typically developing (TD) children. Read more

Publication: Frontiers in Pediatrics, February 2023

Authors: Ashley Ansel, Yehudit Posen, Ronald Ellis, Lisa Deutsch, Philip D. Zisman, and Benjamin Gesundheit

Description: The objective of this paper is to compare the reported accuracy and sensitivity of the various modalities used to diagnose autism spectrum disorders (ASD) in efforts to help focus further biomarker research on the most promising
methods for early diagnosis. Read more

Publication: Rambam Maimonides Medical Journal, October 2019

Editors: Benjamin Gesundheit, Joshua Rosenzweig and Yehuda Shoenfeld

Description: This open-access book compiles evidence of the biological basis of autism spectrum disorders which are setting the stage for understanding the mechanisms underlying the behavioral symptoms of the condition and for development of targeted therapeutics. Read more

Publication: Frontiers in Neuroscience and Frontiers in Pediatrics, February 2017

Authors: Benjamin Gesundheit, Paul Ashwood, Armand Keating, David Naor, Michal Melamed, Joshua P. Rosenzweig

Description: This work presents the rationale behind stem cell-based treatment for autism patients presenting immune and nervous system abnormalities. This approach is regularly applied for the management of a range of immunological and neurological conditions and has proven both effective and safe. Read more

Publication: Medical Hypotheses, December 2014

Authors: Benjamin Gesundheit, Joshua P. Rosenzweig, David Naor, Bernard Lerer, et al.

Description: This paper reviews studies that link between immune dysfunction or abnormalities and autism spectrum disorder. These works bear potential to advance more accurate and objective diagnostics and to identify therapeutic targets for autism management. Read more

Publication: Journal of Autoimmunity, 2013