Another immune-modulating therapy which has been researched for ASD is IVIG- IntraVenous ImmunoGlobulin. Immunoglobulins are antibodies and are part of your blood’s plasma. Human immunoglobulins are extracted from the blood of donors and then injected into the recipient through IV. It is often used as a treatment for those with immunodeficiency, including autoimmune disorders. In the case of ASD- many researchers have found markers in the blood of children with Autism which suggest a type of autoimmune disorder.
“Since we examined 1000 biomarkers in as many as 200 children, we have a unique platform for developing an assay. Cell-El’s large number of subjects and biomarkers is an innovation in the field. Previous Autism studies only examined a small number of markers within small cohorts of children. Autism is a spectrum condition, with a widely heterogeneous population. I believe that only the combination of several different biomarkers can enable us to develop an objective laboratory tool that will distinguish between neuro typically-developing individuals and those who present with ASD.
First of all, one can’t truly research a medical treatment for Autism without understanding the medical condition – what it is that you are treating. I first studied what is unique medically to children with Autism making them different from typically developing children. With that Cell-El began.
Cell-El Ltd. studies stem cell therapy as a possible treatment for immune dysfunction. During the past decade, ASD associated immune dysfunction has been observed in numerous studies. We have also been observing this dysfunction in our diagnostic study of children with ASD as compared with typically developed children. Our working theory is that immune dysfunction is possibly a root cause of ASD behavioral issues.
Cell-El studies stem cell therapy as a possible treatment for immune dysfunction. We have been observing this dysfunction in our diagnostic study of children with ASD. Our working theory is that immune dysfunction is possibly a root cause of ASD behavioral issues. By affecting change at the source, we can bring about change in behavior.
Cell El is focused on developing an objective diagnostic test for Autism Spectrum Disorder (ASD) and researching stem cell transplant treatment for children with ASD. Our main focus will be on the Biomarker test that has the potential to provide early diagnosis of ASD and become a personalized medicine tool for monitoring treatment effects on individual patients.
In Israeli news and media outlets, Ms. Hanna Abramovich of Israel has shared the amazing progress in her son Avi. Avi presents with ASD. A number of years ago he underwent stem cell therapy. She chose the option of autologous stem cells from the child’s own stored umbilical cord blood.
Cell El Ltd. is happy to announce that we are now recruiting infant siblings of children diagnosed with ASD and their mothers for our diagnostic research of ASD biomarkers. The infants (age 10-18 months) have an older sibling diagnosed with ASD and therefore are considered high risk for developing ASD as well.
Cell-El is soaring forward with the development of an objective diagnostic tool for ASD. The tool will enable early detection of ASD with greater certainty and ease than methods currently used. One mother shared with us her frustrating experience with the uncertainty produced by the current means of diagnosis.
Cell-El’s research focused on a comparison between the levels of 1,000 inflammatory/ immune-related biomarkers in the blood of about 100 children diagnosed with ASD compared to 100 neuro-typically developing (TD) children. We arrived at 85% accuracy in using these biomarkers to differentiate between the ASD and TD children.
Cell-El, Ltd. is striving to create a diagnostic test for ASD based on biomarkers. What are biomarkers? A biomarker is a biological indicator that can be measured and tells us something about a normal or abnormal biological state or a response to a therapeutic intervention or drug.
At Cell-El Ltd, we are also taking a high level of interest in Microbiota Transfer Therapy (MTT) – also known as Fecal Microbial Transplantation (FMT) – to repair the microbial biofilms that live in all of our gastro-intestinal (GI) systems as an important part of the human microbiome.
Autism spectrum disorder (ASD) is a developmental disorder, characterized by deficits in communication, social interactions and sensory perception and by repetitive behavior, typically manifesting in the first three years of life. No curative therapies are available to treat the condition, whose causes remain poorly understood.